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KMID : 0043320170400010032
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Archives of Pharmacal Research
2017 Volume.40 No. 1 p.32 ~ p.36
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Versicolols A and B, two new prenylated isocoumarins from endophytic fungus Aspergillus versicolor and their cytotoxic activity
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Zhou Min
Lou Jie
Li Yin Ke
Wang Yue De
Zhou Kun
Ji Bing Kun
Dong Wei
Gao Xue Mei
Du Gang
Hu Qiu Fen
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Abstract
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Versicolols A and B (1 and 2), two rare prenylated isocoumarin derivatives, along with five known isocoumarins (3?7) were isolated from the fermentation products of an endophytic fungus Aspergillus versicolor. Their structures were elucidated on the basis of extensive spectroscopic analysis, including 1D- and 2D-NMR techniques. Compounds 1 and 2 were evaluated for their cytotoxicity against five human tumor cell lines. The results showed that compounds 1 exhibited weak cytotoxicity against A549 and MCF7 cells with IC50 values of 9.4 and 8.8 μm, and compound 2 exhibited weak cytotoxicity against SHSY5Y and MCF7 cells with IC50 values of 8.2 and 6.8 μm, respectively.
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KEYWORD
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Prenylated isocoumarins, Aspergillus versicolor, Cytotoxicity
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